与细胞表面免疫球蛋白独特型和恒定区决定簇反应的绵羊抗体类别和亚类对细胞毒性功能的介导作用。
Mediation of cytotoxic functions by classes and subclasses of sheep antibody reactive with cell surface immunoglobulin idiotypic and constant region determinants.
作者信息
Stevenson F K, Elliott E V
出版信息
Immunology. 1978 Feb;34(2):353-8.
Abstract
Sheep antibodies, reactive with either the idiotypic or constant region antigenic determinants of the immunoglobulin light chain on guinea-pig L2C leukaemic cells, were separated into IgM and into the two subclasses of IgG, IgG1 and IgG2. Antibody of both IgG subclasses inhibited the migration of L2C cells along plastic surfaces; IgM was only weakly inhibitory. Antibody of class IgM and of subclass IgG1 mediated complement cytotoxicity against the L2C cells whereas only that of subclass IgG2 mediated K-cell cytotoxicity; the effector arms were rabbit complement and sheep peripheral leucocytes, respectively.
摘要
与豚鼠L2C白血病细胞免疫球蛋白轻链的独特型或恒定区抗原决定簇发生反应的绵羊抗体，被分离为IgM以及IgG的两个亚类，即IgG1和IgG2。两种IgG亚类的抗体均抑制L2C细胞沿塑料表面的迁移；IgM仅有微弱的抑制作用。IgM类和IgG1亚类的抗体介导针对L2C细胞的补体细胞毒性，而只有IgG2亚类的抗体介导K细胞细胞毒性；效应臂分别是兔补体和绵羊外周血白细胞。
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本文引用的文献
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Induction of T and B cell immunity by anti-idiotypic antibody.抗独特型抗体诱导T细胞和B细胞免疫
Eur J Immunol. 1975 Oct;5(10):661-6. doi: 10.1002/eji.1830051002.
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Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides.通过卤化氰将肽和蛋白质与多糖进行化学偶联。
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The recombination of dimers of immunoglobulin peptide chains.免疫球蛋白肽链二聚体的重组。
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Structural relationship and complement fixing activity of sheep and other ruminant immunoglobulin G subclasses.绵羊及其他反刍动物免疫球蛋白G亚类的结构关系与补体固定活性
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Biological activities of immunoglobulins of different classes and subclasses.不同类别和亚类免疫球蛋白的生物学活性
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Leukocyte-dependent antibody in sheep immunized with murine mastocytoma cells.用鼠肥大细胞瘤细胞免疫的绵羊中的白细胞依赖性抗体。
Eur J Immunol. 1975 May;5(5):324-30. doi: 10.1002/eji.1830050507.
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A gamma Bence-Jones protein in guinea pigs.豚鼠中的一种γ本斯-琼斯蛋白。
Biochem J. 1975 Dec;151(3):751-3. doi: 10.1042/bj1510751.
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Nature. 1975 Apr 24;254(5502):714-6. doi: 10.1038/254714a0.
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