Shin H J, Ro J Y
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Yonsei Med J. 1995 Jul;36(3):215-31. doi: 10.3349/ymj.1995.36.3.215.
The necessity of early detection of prostate cancer renewed interest regarding putative premalignant lesions in the tumorigenesis of the prostate. Prostatic intraepithelial neoplasia (PIN) is one potential precursor for prostatic adenocarcinoma. The term PIN has been adopted to replace a wide range of synonyms in the literature that describe potential precursors. PIN is an intraluminal proliferation of the secretory cells lining architecturally benign prostatic ducts and acini that exhibit cytologic atypia. In this review, we discuss the histologic features, the differential diagnosis, the evidence that PIN is a precursor of prostatic carcinoma, and the clinical significance of PIN.
早期发现前列腺癌的必要性重新引发了人们对前列腺肿瘤发生过程中假定的癌前病变的关注。前列腺上皮内瘤变（PIN）是前列腺腺癌的一种潜在前体。“PIN”这一术语已被采用，以取代文献中描述潜在前体的一系列同义词。PIN是指在结构上良性的前列腺导管和腺泡内衬的分泌细胞的管腔内增殖，这些细胞表现出细胞学异型性。在这篇综述中，我们讨论了PIN的组织学特征、鉴别诊断、PIN是前列腺癌前体的证据以及PIN的临床意义。
