Effect of urecholine and carbacholine on pentagastrin-stimulated gastric secretion after proximal gastric vagotomy in duodenal ulcer patients;

Six months after proximal gastric vagotomy gastric secretion was examined after infusion of pentagastrin, 15 mug/kg/hr, alone and in combination with urecholine, 60 mug/kg/hr, or carbacholine, 2 mug/kg/hr. There were no significant differences between mean acid outputs after the three types of stimulation. Pepsin outputs were significantly higher after pentagastrin plus carbacholine and pentagastrin plus urecholine than after pentagastrin alone. Urecholine and carbacholine increased pepsin secretion to a similar degree. Volume of gastric juice was significantly higher after simultaneous infusion of pentagastrin and urecholine than after pentagastrin alone or pentagastrin plus carbacholine.