检测人体和小鼠体液中甲硝唑和硝唑尼特的诱变活性。
Detection of mutagenic activity of metronidazole and niridazole in body fluids of humans and mice.
作者信息
Legator M S, Connor T H, Stoeckel M
出版信息
Science. 1975 Jun 13;188(4193):1118-9. doi: 10.1126/science.766186.
PMID:766186
Abstract
After humans were treated at therapeutic doses with the trichomonacide metronidazole (Flagyl) and the antischistosomal agent niridazole mutagenic activity was demonstrable in their urines when tested with the histidine auxotroph of Salmonella typhimurium. Both compounds were active in the host-mediated assay in mice, and evidence of activity was found in the blood and urine of mice treated with niridazole but not with metronidazole.
摘要
人类接受治疗剂量的抗滴虫药甲硝唑（灭滴灵）和抗血吸虫药硝唑咪治疗后，当用鼠伤寒沙门氏菌的组氨酸营养缺陷型菌株进行检测时，其尿液中可显示出诱变活性。这两种化合物在小鼠宿主介导试验中均有活性，在用硝唑咪而非甲硝唑治疗的小鼠的血液和尿液中发现了活性证据。
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