来自块茎毛瓣花的多酚类物质。

Polyphenols from Eriosema tuberosum.

作者信息

Ma W G, Fuzzati N, Li Q S, Yang C R, Stoeckli-Evans H, Hostettmann K

机构信息

Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Switzerland.

出版信息

Phytochemistry. 1995 Jul;39(5):1049-61. doi: 10.1016/0031-9422(95)00052-9.

DOI:10.1016/0031-9422(95)00052-9

PMID:7662271

Abstract

A dichloromethane extract of the roots of Eriosema tuberosum exhibited antifungal activity against Cladosporium cucumerinum and Candida albicans using TLC bioautography. Bioassay-directed fractionation led to the isolation of four new compounds, eriosemaones A-D, together with a known compound, flemichin-D, as the active constituents. Three inactive polyphenols were also isolated after methylation, together with one new chromone, eriosematin. Structures were determined by spectroscopic analysis and from chemical evidence.

摘要

采用薄层色谱生物自显影法，发现块茎毛瓣花根的二氯甲烷提取物对黄瓜枝孢菌和白色念珠菌具有抗真菌活性。通过生物活性导向的分级分离，分离得到了四种新化合物，即块茎毛瓣花酮A-D，以及一种已知化合物弗氏菌素-D，它们是活性成分。甲基化后还分离出三种无活性的多酚类化合物，以及一种新的色酮类化合物，即块茎毛瓣花色酮。通过光谱分析和化学证据确定了这些化合物的结构。