Garrido L, Pfleiderer B, Papisov M, Ackerman J L
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129.
Magn Reson Med. 1993 Jun;29(6):839-43. doi: 10.1002/mrm.1910290620.
29Si nuclear magnetic resonance (NMR) spectroscopy is applied to study the degradation of polysiloxanes (silicones) in vivo. Our results with animal models show that silicone migrates from the implant to the liver (29Si resonance at -20 ppm) and new silicon containing compounds form after the silicones are introduced into the rats. The new 29Si resonances in the chemical shift range of -40 to -85 ppm are related to hydrolyzed silicone, those at -90 to -115 ppm are indicative of the presence of silica (SiO2), and the peaks observed at -120 to -150 are related to high coordinated silicon complexes. These resonances are not present in the 29Si spectra of the silicones before implantation. Our findings demonstrate that silicones are not metabolically inert.
应用29Si核磁共振（NMR）光谱法研究聚硅氧烷（硅酮）在体内的降解情况。我们在动物模型上得到的结果表明，硅酮从植入物迁移至肝脏（29Si共振峰位于-20 ppm处），并且在将硅酮引入大鼠体内后会形成新的含硅化合物。化学位移范围在-40至-85 ppm之间的新29Si共振峰与水解的硅酮有关，-90至-115 ppm处的共振峰表明存在二氧化硅（SiO2），而在-120至-150处观察到的峰则与高配位硅配合物有关。这些共振峰在植入前的硅酮29Si光谱中并不存在。我们的研究结果表明，硅酮并非代谢惰性物质。
