Croom W J, Hagler W M, Froetschel M A, Johnson A D
North Carolina State University, Raleigh 27695, USA.
J Anim Sci. 1995 May;73(5):1499-508. doi: 10.2527/1995.7351499x.
The history of "slobbers syndrome," a mycotoxicosis associated with Rhizoctonia leguminicola infestation of pastures and stored forages, is discussed. The chemistry and physiological effects of the two known biologically active alkaloids of R. leguminicola, slaframine and swainsonine, are described. Slaframine administration is generally associated with increased exocrine function, especially salivation. Ingestion of swainsonine may be linked to serious and potentially lethal central nervous system defects similar to that described for locoism. However, the singular effects of these alkaloids do not completely account for the total clinical picture noted in the field during the occurrence of slobbers syndrome. It is possible that this phenomenon is the result of an interaction between both known and unidentified biologically active metabolites of R. leguminicola.
本文讨论了“流涎综合征”的历史，这是一种与牧场和储存饲料中受到豆科丝核菌侵染相关的霉菌毒素中毒症。文中描述了豆科丝核菌两种已知的生物活性生物碱——哌啶生物碱和苦马豆素的化学性质及生理效应。给予哌啶生物碱通常会导致外分泌功能增强，尤其是唾液分泌增加。摄入苦马豆素可能与严重且潜在致命的中枢神经系统缺陷有关，类似于疯草病所描述的情况。然而，这些生物碱的单一作用并不能完全解释流涎综合征发生时在实际情况中所观察到的全部临床症状。这种现象有可能是豆科丝核菌已知和未知生物活性代谢产物之间相互作用的结果。
