吡啶羧酸作为由gabP编码的大肠杆菌gab通透酶的抑制剂和底物。
Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP.
作者信息
King S C, Fleming S R, Brechtel C
机构信息
Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77555-0641, USA.
出版信息
J Bacteriol. 1995 Sep;177(18):5381-2. doi: 10.1128/jb.177.18.5381-5382.1995.
Abstract
Although considered selective for its natural substrate, 4-aminobutyrate, gab permease was inhibited by 1,2,3,6-tetrahydro-3-pyridinecarboxylate and 1,2,3,6-tetrahydro-4-pyridinecarboxylate. The former is a transported substrate, since its preloading into metabolically poisoned cells stimulated transient accumulation of 4-aminobutyrate via counterflow.
摘要
尽管γ-氨基丁酸通透酶被认为对其天然底物4-氨基丁酸具有选择性，但它会受到1,2,3,6-四氢-3-吡啶羧酸酯和1,2,3,6-四氢-4-吡啶羧酸酯的抑制。前者是一种转运底物，因为将其预先加载到代谢中毒的细胞中会通过逆向流动刺激4-氨基丁酸的短暂积累。
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Molecular organization of the Escherichia coli gab cluster: nucleotide sequence of the structural genes gabD and gabP and expression of the GABA permease gene.大肠杆菌gab操纵子的分子组织：结构基因gabD和gabP的核苷酸序列以及GABA通透酶基因的表达
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