Huang T S, Wang Y H, Lien I N
Department of Medicine, National Taiwan University Hospital, Taipei, Republic of China.
Metabolism. 1995 Sep;44(9):1116-20. doi: 10.1016/0026-0495(95)90002-0.
Thirty-two men with spinal cord injury (SCI) were studied for evaluation of the hypothalamus-pituitary somatotrope axis, using growth hormone-(GH)-releasing hormone (GHRH) and insulin-induced hypoglycemia. Twenty-six age-matched normal male volunteers served as controls. Six SCI subjects (18.7%) had elevated basal follicle-stimulating hormone (FSH) levels, eight (25.0%) had hyperprolactinemia, and 11 (34.4%) had reduced serum insulin-like growth factor-1 (IGF-1) levels. Twenty SCI subjects (62.5%) had reduced and/or delayed GH responses to GHRH, and eight (25.8%) had reduced GH response to insulin-induced hypoglycemia. Seven of eight hyperprolactinemic SCI subjects showed reduced GH response to GHRH and/or insulin-induced hypoglycemia. These findings are consistent with the notion that SCI subjects have a reduced central dopaminergic tone.
对32名脊髓损伤（SCI）男性患者进行了研究，采用生长激素释放激素（GHRH）和胰岛素诱发低血糖来评估下丘脑-垂体生长激素轴。26名年龄匹配的正常男性志愿者作为对照。6名SCI患者（18.7%）基础促卵泡生成素（FSH）水平升高，8名（25.0%）有高泌乳素血症，11名（34.4%）血清胰岛素样生长因子-1（IGF-1）水平降低。20名SCI患者（62.5%）对GHRH的生长激素（GH）反应降低和/或延迟，8名（25.8%）对胰岛素诱发低血糖的GH反应降低。8名高泌乳素血症SCI患者中有7名对GHRH和/或胰岛素诱发低血糖的GH反应降低。这些发现与SCI患者中枢多巴胺能张力降低的观点一致。
