Bauman William A, La Fountaine Michael F, Spungen Ann M
J Spinal Cord Med. 2014 Jan;37(1):32-9. doi: 10.1179/2045772313Y.0000000122. Epub 2013 Nov 26.
To describe the relationship of advancing age in persons with chronic spinal cord injury (SCI) on the prevalence of low testosterone in men with SCI compared to historical normative data from able-bodied men in the general population.
Retrospective, cross-sectional study. Two hundred forty-three healthy, non-ambulatory outpatient men with chronic SCI from age of 21 to 78 years were included in this retrospective analysis.
Forty-six percent of men with SCI were identified as having low serum total testosterone concentrations (total testosterone <11.3 nmol/l). The age-related decline in SCI for total serum testosterone concentration was 0.6%/year compared to 0.4%/year in the Massachusetts Male Aging Study. Between the third and eighth decade of life, men with SCI had a 15, 39, 50, 53, 58, and 57% prevalence rate of low serum total testosterone, which is higher than values reported for each decade of life for able-bodied men in the Baltimore Longitudinal Study on Aging.
Compared with the general population, low serum total testosterone concentration occurs earlier in life in men with SCI, at a higher prevalence by decade of life, and their age-related decline in circulating total testosterone concentration is greater. Studies of T replacement therapy in men with SCI should assist in determining the possible functional and clinical benefits from reversing low serum total testosterone concentration.
将慢性脊髓损伤（SCI）患者的年龄增长情况与SCI男性低睾酮患病率相联系，并与普通人群中健全男性的历史标准数据进行比较。
回顾性横断面研究。本回顾性分析纳入了243名年龄在21至78岁之间、健康的、非卧床的慢性SCI门诊男性患者。
46%的SCI男性被确定为血清总睾酮浓度低（总睾酮<11.3 nmol/l）。与马萨诸塞州男性衰老研究中每年0.4%的下降率相比，SCI患者血清总睾酮浓度的年龄相关下降率为每年0.6%。在生命的第三个和第八个十年之间，SCI男性血清总睾酮低的患病率分别为15%、39%、50%、53%、58%和57%，高于巴尔的摩纵向衰老研究中健全男性在每个十年所报告的值。
与普通人群相比，SCI男性血清总睾酮浓度低在生命早期出现，按十年计算患病率更高，且其循环总睾酮浓度的年龄相关下降更大。对SCI男性进行睾酮替代疗法的研究应有助于确定逆转血清总睾酮浓度低可能带来的功能和临床益处。
