Cotter M A, Cameron N E, Keegan A, Dines K C
Department of Biomedical Sciences, University of Aberdeen, Scotland, UK.
Metabolism. 1995 Sep;44(9):1209-14. doi: 10.1016/0026-0495(95)90018-7.
L-Carnitine metabolism is abnormal in diabetes mellitus, and treatment with acetyl-L-carnitine (ALC) improves the function of cardiac muscle, retina, and peripheral nerve in experimental models. The aim was to compare the effects of ALC and proprionyl-L-carnitine (PLC) on motor and sensory nerve conduction in streptozotocin-diabetic rats and to ascertain whether their action could be mediated by a vascular mechanism. ALC and PLC treatment for 2 months after diabetes induction attenuated the development of sciatic motor nerve conduction velocity (NCV) deficits by 59.4% +/- 4.4% and 46.9% +/- 3.2%, respectively. There was a similar level of protection for sensory saphenous NCV (42.9% +/- 6.6% and 47.8% +/- 6.0%, respectively). Neither ALC nor PLC prevented the development of resistance to hypoxic conduction failure (RHCF) in sciatic nerve from diabetic rats. A 46.5% +/- 3.4% deficit in sciatic endoneurial blood flow, measured by microelectrode polarography and hydrogen clearance, in diabetic rats was partially prevented by both ALC (48.7% +/- 6.4%) and PLC (69.4% +/- 10.1%). ALC had no significant effect on blood flow in nondiabetic rats. Thus, the data show that these L-carnitine derivatives have a similar efficacy in preventing nerve dysfunction, which depends on a neurovascular action.
在糖尿病中，左旋肉碱代谢异常，而在实验模型中，用乙酰左旋肉碱（ALC）治疗可改善心肌、视网膜和周围神经的功能。目的是比较ALC和丙酰左旋肉碱（PLC）对链脲佐菌素诱导的糖尿病大鼠运动和感觉神经传导的影响，并确定它们的作用是否可通过血管机制介导。糖尿病诱导后2个月用ALC和PLC治疗分别使坐骨神经运动神经传导速度（NCV）缺陷的发展减缓59.4%±4.4%和46.9%±3.2%。对隐神经感觉NCV的保护水平相似（分别为42.9%±6.6%和47.8%±6.0%）。ALC和PLC均不能阻止糖尿病大鼠坐骨神经对缺氧传导衰竭（RHCF）的耐受性发展。通过微电极极谱法和氢清除法测量，糖尿病大鼠坐骨神经内膜血流量有46.5%±3.4%的缺陷，ALC（48.7%±6.4%）和PLC（69.4%±10.1%）均可部分预防。ALC对非糖尿病大鼠的血流量无显著影响。因此，数据表明这些左旋肉碱衍生物在预防神经功能障碍方面具有相似的疗效，这取决于神经血管作用。
