Lowitt S, Malone J I, Salem A F, Korthals J, Benford S
Department of Pediatrics, University of South Florida, Tampa, USA.
Metabolism. 1995 May;44(5):677-80. doi: 10.1016/0026-0495(95)90128-0.
Acetyl-L-carnitine (ALC) has been shown to facilitate the repair of transected sciatic nerves. The effect of ALC (50 mg/kg/d) on the diminished nerve conduction velocity (NCV) of rats with streptozotocin (STZ)-induced hyperglycemia of 3 weeks' duration was evaluated. The aldose reductase inhibitor, sorbinil, which is reported to normalize the impaired NCV associated with experimental diabetes, was used as a positive control. Aldose reductase inhibitors are thought to have an effect by decreasing peripheral nerve sorbitol content and increasing nerve myo-inositol. Treatment of STZ-diabetic rats with either ALC or sorbinil resulted in normal NCV. Sorbinil treatment was associated with normalized sciatic nerve sorbitol and myo-inositol; ALC treatment did not reduce the elevated sorbitol levels, but sciatic nerve myo-inositol content was no different from nondiabetic levels. Both ALC and sorbinil treatment of STZ-diabetic rats were associated with a reduction in the elevated malondialdehyde (MDA) content of diabetic sciatic nerve, indicating reduced lipid peroxidation. The beneficial effects of sorbinil and ALC on the altered peripheral nerve function associated with diabetes were similar, but their effects on the polyol pathway (frequently implicated in the pathogenesis of peripheral neuropathy) were different.
已证明乙酰左旋肉碱（ALC）有助于修复横断的坐骨神经。评估了ALC（50毫克/千克/天）对链脲佐菌素（STZ）诱导的持续3周高血糖大鼠神经传导速度（NCV）降低的影响。醛糖还原酶抑制剂索比尼尔用作阳性对照，据报道它可使与实验性糖尿病相关的受损NCV恢复正常。醛糖还原酶抑制剂被认为是通过降低周围神经山梨醇含量和增加神经肌醇来发挥作用的。用ALC或索比尼尔治疗STZ糖尿病大鼠均可使NCV恢复正常。索比尼尔治疗可使坐骨神经山梨醇和肌醇恢复正常；ALC治疗并未降低升高的山梨醇水平，但坐骨神经肌醇含量与非糖尿病水平无差异。用ALC和索比尼尔治疗STZ糖尿病大鼠均与糖尿病坐骨神经中升高的丙二醛（MDA）含量降低有关，表明脂质过氧化减少。索比尼尔和ALC对与糖尿病相关的周围神经功能改变的有益作用相似，但它们对多元醇途径（常与周围神经病变的发病机制有关）的作用不同。
