Wattiaux M J, Ginsburg C, Giral P, Bennani M, Bigel P, Wioland M, Cabane J, Imbert J C
Service de Médecine interne, Hôpital Saint-Antoine Paris.
Presse Med. 1995 Jun 10;24(21):983-6.
The natural clinical course of primary Sjögren's syndrome was followed in 8 patients to identify the concomitant functional, clinical, biological, scintigraphic and histological manifestations of the disease.
The diagnosis of primary Sjögren's syndrome was made on the basis of functional signs (ocular or salivary sicca syndrome) and 2 positive tests among the 3 objective ocular tests (Schirmer's test, break-up time, Rose Bengale). Work-up included recording of functional and clinical signs, ophthalmologic examination and laboratory tests at diagnosis and every 3 months for 12 months. Scintigraphy of the salivary glands was performed together with a biopsy at diagnosis and at 12 months.
No one parameter varied significantly over a 1 year period demonstrating the lack of need for renewed examinations for diagnosis or regular follow-up.
This is the first report providing a homogeneous series studied by one team over a determined period of time. It demonstrates that clinical, biological and anatomic criteria for primary Sjögren's syndrome do not show any correlation between functional signs and objective ocular tests.
对8例原发性干燥综合征患者的自然临床病程进行跟踪，以确定该疾病伴随的功能、临床、生物学、闪烁扫描及组织学表现。
原发性干燥综合征的诊断基于功能体征（眼或唾液干燥综合征）以及3项客观眼部检查（泪液分泌试验、泪膜破裂时间、孟加拉玫瑰红染色）中的2项阳性结果。检查工作包括在诊断时以及之后12个月内每3个月记录功能和临床体征、进行眼科检查及实验室检测。在诊断时和12个月时对唾液腺进行闪烁扫描并同时进行活检。
在1年期间内，没有一个参数有显著变化，这表明无需为诊断或定期随访而重新进行检查。
这是首篇由一个团队在一段确定时间内对一组同类病例进行研究的报告。该报告表明，原发性干燥综合征的临床、生物学及解剖学标准在功能体征与客观眼部检查之间未显示出任何相关性。
