Saxena P R
Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, The Netherlands.
Pharmacol Ther. 1995 May;66(2):339-68. doi: 10.1016/0163-7258(94)00005-n.
Recent, rapid progress in the molecular biology of serotonin (5-HT) receptors requires conceptual re-thinking with respect to receptor classification. Thus, based on operational criteria (agonist and antagonist rank order), as well as transduction mechanisms involved and the structure of the receptor protein, the Nomenclature Committee of the Serotonin Club has proposed the following classification and nomenclature: the main receptor types 5-HT1 to 5-HT4, recombinant receptors (e.g. 5-ht5 to 5-ht7) and 'orphan' receptors. The aim of the present review is to discuss the events leading to this classification, the criteria for and functional responses mediated by various 5-HT receptors, as well as the therapeutic possibilities with 5-HT ligands.
近年来，血清素（5-羟色胺，5-HT）受体分子生物学取得了迅速进展，这就需要在受体分类方面进行重新思考。因此，基于操作标准（激动剂和拮抗剂的效价顺序）、所涉及的转导机制以及受体蛋白的结构，血清素俱乐部命名委员会提出了以下分类和命名：主要受体类型5-HT1至5-HT4、重组受体（如5-ht5至5-ht7）和“孤儿”受体。本综述的目的是讨论促成这种分类的相关情况、各种5-HT受体的分类标准及其介导的功能反应，以及5-HT配体的治疗可能性。
