Currie G A, Eccles S A
Br J Cancer. 1976 Jan;33(1):51-9. doi: 10.1038/bjc.1976.6.
With progressive growth of syngeneic sarcomata in rats there was a rise in serum levels of lysozyme which correlated with their immunogenicity and their macrophage content. By an examination of lymph/blood differences in normal and in tumour bearing rats and of the production of lysozyme by cells obtained from the tumours and maintained in vitro, it is apparent that the macrophages resident in a tumour mass make a massive contribution to the elevation in serum lysozyme concentrations. Tumour cells did not release detectable lysozyme activity. Tumour amputation led to a rapid fall in lysozyme levels. Irradiation of the host rats abolished the lysozyme response and the subsequent development of metastases in these rats was associated with a rise in serum lysozyme. The serum concentration of this enzyme reflects the macrophage content of a tumour mass and the draining lymph nodes. We conclude that under well defined conditions serum lysozyme activity may be a useful marker of macrophage mediated host responses to a tumour.
随着大鼠同基因肉瘤的逐渐生长，血清溶菌酶水平升高，这与其免疫原性和巨噬细胞含量相关。通过检查正常大鼠和荷瘤大鼠的淋巴/血液差异，以及从肿瘤中获取并在体外培养的细胞产生溶菌酶的情况，很明显肿瘤块中的巨噬细胞对血清溶菌酶浓度的升高起了巨大作用。肿瘤细胞未释放可检测到的溶菌酶活性。肿瘤切除导致溶菌酶水平迅速下降。对宿主大鼠进行照射消除了溶菌酶反应，这些大鼠随后发生转移与血清溶菌酶升高有关。这种酶的血清浓度反映了肿瘤块和引流淋巴结中的巨噬细胞含量。我们得出结论，在明确的条件下，血清溶菌酶活性可能是巨噬细胞介导的宿主对肿瘤反应的有用标志物。
