Baran R, Perrin C
Department of Histopathology, Hopital Pasteur, Nice, France.
Br J Dermatol. 1995 Jul;133(1):77-82. doi: 10.1111/j.1365-2133.1995.tb02496.x.
Isolated distal subungual keratosis refers to a clinical monomorphic lesion involving one digit, but presenting different histological patterns. Among these, in four similar cases, we have observed the presence of multinucleate cells in localized distal subungual keratosis without an intervening granular layer, and without any clinical evidence of Darier's disease. To our knowledge, this constellation of anatomical and clinical features has not been reported previously.
孤立性远端甲下角化病是指一种累及单个手指的临床单形性损害，但呈现不同的组织学模式。其中，在4例类似病例中，我们观察到局限性远端甲下角化病中存在多核细胞，无颗粒层间隔，且无任何 Darier 病的临床证据。据我们所知，这种解剖学和临床特征的组合此前尚未见报道。
