Brandorff N P, Flyvholm M A, Beck I D, Skov T, Bach E
National Institute of Occupational Health, Copenhagen, Denmark.
Occup Environ Med. 1995 Jul;52(7):454-63. doi: 10.1136/oem.52.7.454.
To obtain knowledge about the use and distribution of hazardous chemicals in Danish industry. This knowledge is used to regulate the occupational environment and prevent hazardous exposure.
A national survey on the use of chemicals was carried out in 1989 in a stratified sample of 1448 Danish businesses. 13,000 different chemical products were reported. Information on components in the chemical products was obtained from the Danish product register data base (PROBAS) and by inquiries to suppliers and manufacturers. At the end of the study the composition of about 9400 of the products was known. A model was developed to estimate national numbers of chemical exposure events as a supplement to data on weights of chemicals used.
Data are presented for 36 chemical substances with chronic toxic effects and high estimated national numbers of exposure events for the industry groups included in the survey. Seven of the 36 substances are carcinogens, 17 are reproductive toxicants, 12 are allergens, and 18 are neurotoxicants according to listings of chronic toxicants used by the Danish authorities. The largest national number of exposure events was estimated for the industry groups manufacture of fabricated metal products, and personal services, cleaning, and hair dressing. These should have special attention in further preventive work.
This survey on the use of chemicals is the first nationwide investigation in Denmark to delineate the use of all chemicals. The data have been used in a project to review occupational hazards in general in Danish industry. In the future, the data may be used as a basis for measuring chemical substitution, developing chemical safety, and as reference for more specific investigations and for follow up studies. Also job exposure matrices based on actual use of chemical products can be constructed.
了解丹麦工业中危险化学品的使用和分布情况。这些信息用于规范职业环境并预防有害暴露。
1989年对1448家丹麦企业的分层样本进行了化学品使用情况的全国性调查。共报告了13000种不同的化学产品。化学产品成分信息来自丹麦产品登记数据库(PROBAS),并通过向供应商和制造商咨询获取。研究结束时,约9400种产品的成分已明确。开发了一个模型来估计全国化学暴露事件的数量,作为对所用化学品重量数据的补充。
列出了36种具有慢性毒性作用的化学物质的数据,以及调查中所涵盖行业组估计的全国高暴露事件数量。根据丹麦当局使用的慢性毒物清单,这36种物质中有7种是致癌物,17种是生殖毒物,12种是过敏原,18种是神经毒物。估计全国暴露事件数量最多的行业组是金属制品制造业、个人服务、清洁和美发业。在进一步的预防工作中应特别关注这些行业。
本次化学品使用情况调查是丹麦首次全国性的全面化学品使用情况调查。这些数据已用于一个审查丹麦工业总体职业危害的项目。未来,这些数据可作为衡量化学物质替代情况、发展化学安全的基础,以及更具体调查和后续研究的参考。还可构建基于化学产品实际使用情况的工作场所暴露矩阵。