Monda M, Amaro S, Sullo A, De Luca B
Department of Human Physiology and Integrated Biological Functions F. Bottazzi, Second University of Naples, Italy.
Neuroreport. 1994 Dec 30;6(1):135-9. doi: 10.1097/00001756-199412300-00035.
The firing rate of the posterior hypothalamic neurones and interscapular brown adipose tissue and colonic temperatures (TIBAT and TC) were monitored in 36 urethane-anaesthetized male Sprague-Dawley rats before and after an intracerebroventricular (i.c.v.) injection of 400 ng prostaglandin E1 (PGE1) or saline. The i.c.v. injection was preceded by functional decortication in half of each group. The results show an increase of firing rate, TIBAT and TC after PGE1 injection in the rats without decortication. Functional decortication significantly reduced these enhancements. These findings demonstrate that the posterior hypothalamus plays a significant role in the hyperthermia induced by PGE1 and that the cerebral cortex is involved in the control of posterior hypothalamic activity.
在36只经氨基甲酸乙酯麻醉的雄性Sprague-Dawley大鼠中，于脑室内（i.c.v.）注射400 ng前列腺素E1（PGE1）或生理盐水前后，监测下丘脑后部神经元的放电频率、肩胛间棕色脂肪组织温度和结肠温度（TIBAT和TC）。每组半数大鼠在脑室内注射前进行功能性去皮质。结果显示，未去皮质的大鼠注射PGE1后，放电频率、TIBAT和TC均增加。功能性去皮质显著降低了这些增强作用。这些发现表明，下丘脑后部在PGE1诱导的体温升高中起重要作用，且大脑皮质参与了下丘脑后部活动的控制。
