Masson M
Fortschr Med. 1995 Jul 10;113(19):303-6.
In an open case observation study involving patients with blunt injuries to the musculoskeletal system, the efficacy and tolerability of high-dose Bromelain POS, a plant-derived enzyme preparation, were investigated. The investigating physician was an orthopedic surgeon who, in addition to the usual therapeutic measures, treated 59 of his patients with the bromelaine preparation. The duration of the application was determined by the nature and severity of the lesion, and varied between one and three weeks. The test criteria were swelling, pain at rest and during movement, and tenderness. These parameters were evaluated on the day of the injury and on five subsequent dates.
Treatment with bromelaine resulted in a clear reduction in all four parameters tested. Both swelling and the symptoms of pain had improved appreciably at all evaluation time points as compared with baseline. The tolerability of the preparation was very good, and patient compliance was correspondingly high.
在一项针对肌肉骨骼系统钝性损伤患者的开放性病例观察研究中，对一种植物源酶制剂高剂量菠萝蛋白酶（Bromelain POS）的疗效和耐受性进行了研究。研究医生为一名骨科外科医生，除常规治疗措施外，他用菠萝蛋白酶制剂治疗了59例患者。用药持续时间根据损伤的性质和严重程度确定，在1至3周之间变化。测试标准包括肿胀、静息及活动时的疼痛以及压痛。这些参数在受伤当天及随后的五个日期进行评估。
菠萝蛋白酶治疗使所有四个测试参数均明显降低。与基线相比，在所有评估时间点，肿胀和疼痛症状均有明显改善。该制剂的耐受性非常好，患者依从性相应较高。
