磷脂对大肠杆菌DNA聚合酶I活性的影响。
Effect of phospholipids on the activity of DNA polymerase I from E. coli.
作者信息
Novello F, Muchmore J H, Bonora B, Capitani S, Manzoli F A
出版信息
Ital J Biochem. 1975 Nov-Dec;24(6):325-34.
PMID:767289
Abstract
Sphingomyelin, phosphatidylethanolamine and lecithin at concentrations which destabilize the DNA helix enhance the DNA polymerase activity, but sphingosine and phosphatidylserine have only a moderate effect. MgCl2 was shown to modify the action of sphingomyelin on the DNA polymerase activity. The role of phospholipids in the DNA replicating process was analyzed.
摘要
鞘磷脂、磷脂酰乙醇胺和卵磷脂在使DNA螺旋不稳定的浓度下可增强DNA聚合酶活性，但鞘氨醇和磷脂酰丝氨酸的作用仅为中等程度。已表明MgCl2可改变鞘磷脂对DNA聚合酶活性的作用。分析了磷脂在DNA复制过程中的作用。
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