克罗米芬对绝经后妇女基础促性腺激素分泌及促黄体生成素释放激素诱导的促性腺激素分泌的影响。

Effect of clomiphene on basal and LRH-induced gonadotropin secretion in postmenopausal women.

作者信息

Hashimoto T, Miyai K, Izumi K, Kumahara Y

出版信息

J Clin Endocrinol Metab. 1976 Mar;42(3):593-4. doi: 10.1210/jcem-42-3-593.

Abstract

LRH tests were performed in 11 postmenopausal women before and after the administration of 200 mg of clomiphene citrate daily by mouth for 7 consecutive days. The basal levels and the maximum increments of serum LH (deltaLH) and the area under the response curve from basal level (deltaarea) after LRH administration, significantly (P less than 0.005) decreased after consecutive administration of this compound. Serum FSH levels were significantly (P less than 0.025) decreased but deltaFSH and deltaarea in LRH test were statistically unchanged. These results suggest that clomiphene citrate in postmenopausal women inhibits the pituitary gonadotropin response to exogenous LRH by its estrogenic effects.

摘要

对11名绝经后妇女进行了促黄体激素释放激素（LRH）试验，在连续7天每天口服200毫克枸橼酸氯米芬前后分别进行。连续服用该化合物后，促黄体生成素（LH）的基础水平和最大增加值（deltaLH）以及LRH给药后从基础水平开始的反应曲线下面积（deltaarea）显著（P<0.005）降低。血清促卵泡生成素（FSH）水平显著（P<0.025）降低，但LRH试验中的deltaFSH和deltaarea在统计学上无变化。这些结果表明，绝经后妇女体内的枸橼酸氯米芬通过其雌激素作用抑制垂体促性腺激素对外源性LRH的反应。