Hashimoto T, Miyai K, Izumi K, Onishi T, Kumahara Y
Endocrinol Jpn. 1976 Apr;23(2):115-8. doi: 10.1507/endocrj1954.23.115.
Fifteen postmenopusal women were given 25 mg, 50 mg of clomiphene citrate daily by mouth for 3 consecutive days. Significant (p less than 0.01)decrease of serum LH (73%, 65%) and FSH (76%, 76%) resulted after administration of 25 mg and 50 mg clomiphene citrate respectively. The suppressive effect was sustained for at least 4 days after cessation of this drug. On other hand decreased LH and FSH levels after administration of ethinyl estradiol increased again by simultaneous administration of clomiphene citrate. These results suggest deficient subjects but anti-estrogenic effects are evident when serum estrogen levels are restored in subjects with estrogen deficiency.
15名绝经后女性连续3天每天口服25毫克、50毫克枸橼酸氯米芬。分别服用25毫克和50毫克枸橼酸氯米芬后，血清促黄体生成素（LH）（分别下降73%、65%）和促卵泡生成素（FSH）（分别下降76%、76%）出现显著（p<0.01）下降。停药后，这种抑制作用至少持续4天。另一方面，同时服用枸橼酸氯米芬后，乙炔雌二醇给药后降低的LH和FSH水平再次升高。这些结果表明，在雌激素缺乏的受试者中，当血清雌激素水平恢复时，存在抗雌激素作用，但在雌激素缺乏的受试者中，抗雌激素作用明显。
