Galer B S, Butler S, Jensen M P
Chronic Pain Services, University of Washington School of Medicine, Seattle, Washington, USA.
J Pain Symptom Manage. 1995 Jul;10(5):385-91. doi: 10.1016/0885-3924(95)00061-3.
Reflex sympathetic dystrophy (RSD, Complex Regional Pain Syndrome-1, CRPS-1) is a chronic pain disorder associated with autonomic dysregulation that most commonly involves a limb. In addition to pain, motor dysfunction in the involved extremity may be a significant cause of disability. To spur reassessment of underlying mechanisms and development of novel rehabilitative approaches for RSD, we propose a new hypothesis: a neurologic neglect-like syndrome may explain the motor dysfunction that occurs in a subgroup of RSD patients. This hypothesis is based on a selected series of 11 patients who underwent specific neglect testing. The etiology of neglect in RSD is not clear, but we hypothesize that changes within central nervous system (CNS) structures may occur following persistent abnormal activation of the peripheral and autonomic nervous systems, which then may result in a neglect-like syndrome. Further study is needed to verify our clinical observations and test this hypothesis.
反射性交感神经营养不良（RSD，复杂性区域疼痛综合征-1，CRPS-1）是一种与自主神经调节异常相关的慢性疼痛障碍，最常累及肢体。除疼痛外，受累肢体的运动功能障碍可能是导致残疾的重要原因。为推动对RSD潜在机制的重新评估以及开发新的康复方法，我们提出一个新假说：一种类似神经忽视的综合征可能解释RSD患者亚组中出现的运动功能障碍。该假说基于对11例接受特定忽视测试的患者的选定系列研究。RSD中忽视的病因尚不清楚，但我们推测，外周和自主神经系统持续异常激活后，中枢神经系统（CNS）结构可能发生变化，进而可能导致类似忽视的综合征。需要进一步研究来验证我们的临床观察结果并检验这一假说。
