Tews D S, Pongratz D E
Division of Neuropathy, University of Mainz, Germany.
J Neurol Neurosurg Psychiatry. 1995 Sep;59(3):322-5. doi: 10.1136/jnnp.59.3.322.
In six cases of granulomatous myopathy immunohistological analysis showed a typical pattern with macrophages and T4 cells diffusely distributed throughout the cellular exudate. T8 lymphocytes were interspersed irregularly within the granulomatous cellular infiltrate early in granuloma maturation and in later stages predominantly confined to a lymphocytic mantle surrounding the granulomas. The cellular infiltrate displayed numerous activated HLA-DR and interleukin-2 receptor positive cells including cell proliferation. Increased connective tissue showed strong immunoreactivity for fibronectin and hyaluronate. Muscle fibres were negative for MHC class I molecules. Atrophic muscle fibres expressed desmin, a marker to distinguish desmin positive myogenic giant cells from desmin negative Langhans giant cells.
在6例肉芽肿性肌病患者中，免疫组织学分析显示出一种典型模式，巨噬细胞和T4细胞弥漫分布于整个细胞渗出物中。在肉芽肿成熟早期，T8淋巴细胞不规则地散布在肉芽肿性细胞浸润内，而在后期主要局限于围绕肉芽肿的淋巴细胞套。细胞浸润显示出大量活化的HLA-DR和白细胞介素-2受体阳性细胞，包括细胞增殖。结缔组织增多对纤连蛋白和透明质酸显示出强烈的免疫反应性。肌纤维对MHC I类分子呈阴性。萎缩的肌纤维表达结蛋白，这是一种区分结蛋白阳性肌源性巨细胞和结蛋白阴性朗汉斯巨细胞的标志物。
