Kramer K, Grimbergen J A, van der Gracht L, van Iperen D J, Jonker R J, Bast A
Leiden/Amsterdam Center for Drug Research, Department of Pharmacochemistry, The Netherlands.
Methods Find Exp Clin Pharmacol. 1995 Mar;17(2):107-12.
Measurement of parameters from the circulatory system of laboratory animals can play an important role in pharmacological or toxicological research. To study the mutual interaction between physical exercise and antioxidant systems in rats, we selected swimming as a model for exercise performance. Swimming belongs to the natural behavior of the rat, and under proper experimental conditions, it primarily involves physical exercise with little emotional arousal. Therefore, we developed a swimming basin in which the intensity of exercise could be manipulated through speed and duration of swimming. A laser beam interruption system enables the rat to be followed during each swimming session. A motor-controlled following device, consisting of a rail and sledge connected to a position sensor, contains an antenna mounted in a receiver board. In this way, we can record the electrocardiogram (ECG) and heart rate (HR) with a commercially available telemetry transmitter implanted in the peritoneal cavity of freely swimming rats and evaluate the physical fitness (condition) of the swim-trained rats.
测量实验动物循环系统的参数在药理学或毒理学研究中可发挥重要作用。为了研究大鼠体育锻炼与抗氧化系统之间的相互作用，我们选择游泳作为运动表现的模型。游泳属于大鼠的自然行为，在适当的实验条件下，它主要涉及体育锻炼，几乎没有情绪唤起。因此，我们开发了一个游泳池，在其中可以通过游泳速度和持续时间来控制运动强度。激光束中断系统能够在每次游泳过程中跟踪大鼠。一个由轨道和连接到位置传感器的雪橇组成的电机控制跟踪装置，包含一个安装在接收板上的天线。通过这种方式，我们可以使用植入自由游泳大鼠腹腔的市售遥测发射器记录心电图（ECG）和心率（HR），并评估游泳训练大鼠的体能（状况）。
