Ikeda M, Dewar D, McCulloch J
Wellcome Surgical Institute, University of Glasgow, UK.
Neurosci Lett. 1995 Jun 2;192(1):37-40. doi: 10.1016/0304-3940(95)11602-s.
Galanin receptor binding sites were examined in the inferior temporal and medial occipital gyri of patients with Alzheimer's disease (AD) and matched control subjects using quantitative autoradiography. In the inferior temporal gyrus, galanin binding was reduced selectively in layers V-VI of the AD cases compared to controls, the magnitude of the reduction (45%) being similar to that of choline acetyltransferase activity (40%) in this region. In the medial occipital gyrus, galanin binding in the AD cases was not different from controls in any cortical layer despite a reduction in choline acetyltransferase activity. Galanin binding did not correlate with the densities of neuritic plaques in either temporal or occipital gyri. Thus, despite a significant cortical cholinergic deficit in AD, there is an anatomically selective reduction of cortical galanin receptor binding sites suggesting that the majority of galanin receptors are not located on cholinergic terminals in the human cerebral cortex.
利用定量放射自显影技术，在阿尔茨海默病（AD）患者的颞下回和枕内侧回以及匹配的对照受试者中检测了甘丙肽受体结合位点。在颞下回，与对照组相比，AD患者的V-VI层中甘丙肽结合选择性降低，降低幅度（45%）与该区域胆碱乙酰转移酶活性的降低幅度（40%）相似。在枕内侧回，尽管胆碱乙酰转移酶活性降低，但AD患者在任何皮质层中的甘丙肽结合与对照组并无差异。甘丙肽结合与颞叶或枕叶回中神经炎性斑块的密度均无相关性。因此，尽管AD患者存在明显的皮质胆碱能缺陷，但皮质甘丙肽受体结合位点在解剖学上有选择性降低，这表明人类大脑皮质中大多数甘丙肽受体并不位于胆碱能终末上。
