Sihvonen L, Kulonen K, Neuvonen E
National Veterinary and Food Research Institute, Department of Production and Vaccines, Helsinki, Finland.
Acta Vet Scand. 1994;35(4):371-6. doi: 10.1186/BF03548310.
Twenty-one heads of cattle were vaccinated with Madibovin, 31 with Rabdomun and 127 with Rabisin on 4 different farms. Rabies neutralizing antibody titre (> or = 0.5 IU/ml) was detected in 80% of 163 animals tested about 1 month and in 42% of 133 animals tested about 1 year after primary vaccination. On 3 of the farms 86 animals received booster vaccination about 1 year after primary vaccination. All these animals had antibody titre (> or = 0.5 IU/ml) about 1 month after booster and antibody levels were higher than after the primary vaccination. Rabies antibody titres (> or = 0.5 IU/ml) were detected in 96% of 50 animals tested 1 year after the booster. No significant differences (p > 0.05) in antibody levels were detected between animals vaccinated with Madibovin or Rabisin (farm C) respectively with Rabisin or Rabdomun (farm D) at any collection time. Responses to rabies vaccines varied considerably between the farms. After primary vaccination of the animals on 2 farms with the same batch of Rabisin, the antibody levels clearly differed (p < 0.0001) between the farms. Our results indicate that booster is always necessary after primary vaccination to ensure that all animals are protected.
在4个不同农场，21头牛接种了Madibovin疫苗，31头牛接种了Rabdomun疫苗，127头牛接种了Rabisin疫苗。初次接种疫苗约1个月后，在163只受试动物中有80%检测到狂犬病中和抗体滴度（≥0.5 IU/ml）；初次接种疫苗约1年后，在133只受试动物中有42%检测到该抗体滴度。在3个农场，86只动物在初次接种疫苗约1年后接受了加强免疫。所有这些动物在加强免疫约1个月后都有抗体滴度（≥0.5 IU/ml），且抗体水平高于初次接种疫苗后。在加强免疫1年后检测的50只动物中，有96%检测到狂犬病抗体滴度（≥0.5 IU/ml）。在任何采集时间，分别用Madibovin或Rabisin（农场C）以及用Rabisin或Rabdomun（农场D）接种疫苗的动物之间，抗体水平均未检测到显著差异（p>0.05）。不同农场对狂犬病疫苗的反应差异很大。在2个农场用同一批Rabisin对动物进行初次接种后，农场之间的抗体水平明显不同（p<0.0001）。我们的结果表明，初次接种疫苗后始终需要进行加强免疫，以确保所有动物都得到保护。
