Lincoln T M, Cornwell T L
Department of Pathology, University of Alabama, Birmingham 35294-0019.
FASEB J. 1993 Feb 1;7(2):328-38. doi: 10.1096/fasebj.7.2.7680013.
Cyclic GMP is recognized as an important intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated ion channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. This means that cGMP can alter cell function through protein phosphorylation or through mechanisms not directly related to protein phosphorylation. Cyclic GMP appears to regulate a number of intracellular processes, such as vascular smooth muscle relaxation and neutrophil activation, through these receptor proteins in the cell. It is also becoming clear that the localization of these cGMP receptor proteins in the cell is an important factor in the regulation of cell function by cGMP.
环磷酸鸟苷（cGMP）被认为是细胞外信号（如一氧化氮和利钠肽）的重要细胞内介质。cGMP与三种类型的细胞内受体蛋白相互作用：cGMP依赖性蛋白激酶、cGMP调节离子通道和cGMP调节的环核苷酸磷酸二酯酶。这意味着cGMP可以通过蛋白质磷酸化或通过与蛋白质磷酸化不直接相关的机制改变细胞功能。环磷酸鸟苷似乎通过细胞内的这些受体蛋白调节许多细胞内过程，如血管平滑肌舒张和中性粒细胞激活。同样越来越清楚的是，这些cGMP受体蛋白在细胞内的定位是cGMP调节细胞功能的一个重要因素。
