Itoh F, Komatsu Y, Taya F, Isaji M, Kojima M, Momose Y, Suzawa H, Miyata H, Shibazaki T
Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd., Nagano, Japan.
Nihon Yakurigaku Zasshi. 1993 Jan;101(1):27-32. doi: 10.1254/fpj.101.1_27.
The effect of the ophthalmic solution of tranilast, an anti-allergic agent, on allergic conjunctivitis was studied in passively sensitized guinea pigs. We determined the content of uranine dye and histamine in tears and histopathologically examined palpebral conjunctiva. After instillation of antigen into the conjunctival sac, inflammation of the palpebral conjunctiva, an increase in leaked dye and the release of histamine were found. In the histopathological study, tranilast (1.0%) suppressed the appearance of edema and infiltration of inflammatory cells. Tranilast suppressed the leakage of uranine in a dose-dependent manner. A 0.5% solution of diphenhydramine also showed the inhibitory effect on the leakage of uranine. The inhibitory effect of 0.5% tranilast on antigen-induced dye leakage and histamine release lasted for 6 hr. These results suggest that topically applied tranilast is effective for allergic conjunctivitis.
在被动致敏的豚鼠中研究了抗过敏药曲尼司特滴眼液对过敏性结膜炎的作用。我们测定了泪液中荧光素钠染料和组胺的含量，并对睑结膜进行了组织病理学检查。向结膜囊中滴注抗原后，发现睑结膜出现炎症、漏出染料增加以及组胺释放。在组织病理学研究中，曲尼司特（1.0%）可抑制水肿的出现和炎性细胞浸润。曲尼司特以剂量依赖的方式抑制荧光素钠的渗漏。0.5%的苯海拉明溶液对荧光素钠的渗漏也有抑制作用。0.5%曲尼司特对抗原诱导的染料渗漏和组胺释放的抑制作用持续6小时。这些结果表明，局部应用曲尼司特对过敏性结膜炎有效。
