Kakegawa H, Matsumoto H, Satoh T
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Chem Pharm Bull (Tokyo). 1992 Jun;40(6):1439-42. doi: 10.1248/cpb.40.1439.
The anti-allergic drugs disodium cromoglycate (DSCG) and tranilast are strong inhibitors of hyaluronidase. In the development of new anti-allergic drugs, we studied the inhibitory effects of some natural products on the activation of hyaluronidase. Among the compounds tested, liquiritigenin, isoliquiritigenin and baicalein showed dose-related inhibitory effects. Anti-allergic activities of these compounds were evident from the facts that they inhibited the histamine release from rat peritoneal exudate cells induced by antigen, compound 48/80 and calcium ionophore A-23187, and from their inhibitory effect on Shultz-Dale reaction using sensitized guinea pig ileum.
抗过敏药物色甘酸钠（DSCG）和曲尼司特是透明质酸酶的强效抑制剂。在新型抗过敏药物的研发过程中，我们研究了一些天然产物对透明质酸酶激活的抑制作用。在所测试的化合物中，甘草素、异甘草素和黄芩苷呈现出剂量相关的抑制作用。这些化合物的抗过敏活性从以下事实中得以体现：它们抑制了由抗原、化合物48/80和钙离子载体A-23187诱导的大鼠腹腔渗出细胞释放组胺，并且对致敏豚鼠回肠的舒尔茨-戴尔反应具有抑制作用。
