Honda T, Sadamori N, Itoh M, Kusumi O
Department of Radiobiology, Radiation Effects Research Foundation, Nagasaki Japan.
Mutat Res. 1993 Apr;291(2):125-33. doi: 10.1016/0165-1161(93)90151-o.
Two clonal fibroblast cell lines with simple chromosome aberrations-one with del(3)(p24) and the other with t(1;16)(q21;q11.2)-were established from a high dose (5.14 Gy) female atomic bomb survivor by serial culture of skin fibroblasts. These two types of clonal cells showed a more extended life span than did the cells with 44 other types of chromosome aberrations and normal cells. In addition to these results, a prominent clonal population was observed in the peripheral blood cells in this subject. It is assumed that these clonal populations arose in vivo as a result of radiation exposure to the atomic bomb.
通过对一名高剂量（5.14戈瑞）女性原子弹幸存者的皮肤成纤维细胞进行连续培养，建立了两个具有简单染色体畸变的克隆成纤维细胞系——一个带有3号染色体短臂24区缺失（del(3)(p24)），另一个带有1号和16号染色体易位（t(1;16)(q21;q11.2)）。这两种克隆细胞比具有其他44种染色体畸变的细胞以及正常细胞表现出更长的寿命。除了这些结果外，在该受试者的外周血细胞中还观察到一个显著的克隆群体。据推测，这些克隆群体是原子弹辐射暴露在体内产生的结果。
