Kitajiri M, Kubo N, Ikeda H, Sato K, Kumazawa T
Department of Otolaryngology, Kansai Medical University, Osaka, Japan.
Acta Otolaryngol Suppl. 1993;500:88-91. doi: 10.3109/00016489309126188.
Effects of capsaicin on autonomic nerves in the nasal mucosa and olfactory bulb of toluene diisocyanate sensitized guinea pigs were studied using immunocytochemistry. In the nasal mucosa, substance P (SP)- and tyrosine hydroxylase (TH)-like immunoreactive (SPI and THI) fibers seemed to decrease after capsaicin application. Calcitonin gene-related peptide (CGRP)-like immunoreactive (CGRPI) fibers did not show obvious alterations. In the olfactory bulb, SPI and CGRPI fibers were few and the effects of capsaicin on those fibers were difficult to evaluate. THI fibers seemed not to be affected by capsaicin. It is suggested that capsaicin affects not only sensory nerves but that it also impacts on THI sympathetic nerves in the nasal mucosa.
采用免疫细胞化学方法研究了辣椒素对甲苯二异氰酸酯致敏豚鼠鼻黏膜和嗅球自主神经的影响。在鼻黏膜中，应用辣椒素后，P物质（SP）和酪氨酸羟化酶（TH）样免疫反应性（SPI和THI）纤维似乎减少。降钙素基因相关肽（CGRP）样免疫反应性（CGRPI）纤维未显示明显变化。在嗅球中，SPI和CGRPI纤维很少，辣椒素对这些纤维的影响难以评估。THI纤维似乎不受辣椒素影响。提示辣椒素不仅影响感觉神经，还对鼻黏膜中的THI交感神经有影响。
