Petrasch S G, Mlynek-Kersjes M L, Haase R, Benker G, Olbricht T, Paar D, Reinwein D
Medizinische Klinik und Poliklinik, Universitätsklinikum Essen.
Clin Investig. 1993 Jan;71(1):27-30. doi: 10.1007/BF00210959.
Since in the literature basophilia is frequently related to myxedema, we evaluated basophilic leukocytes in patients with hypothyroidism, applying routine techniques used in clinical laboratories. The study included normal persons, untreated patients with hypothyroidism, and euthyroid subjects with hyperlipidemia. The number of circulating basophils was determined by differential counts of Pappenheim stained blood smears. No difference in relative and total basophil counts was detected in patients with hypothyroidism as compared to healthy controls (1.0% and 58.1 basophils/microliters vs. 0.8% and 50.8 basophils/microliters, respectively). The percentage of basophils in myxedema associated with hypercholesterolemia amounted to 1.0%, their absolute number to 57.6/microliters; in hypothyroid patients presenting normal serum cholesterol levels, the relative and absolute numbers of basophilic leukocytes was not statistically different (0.83% and 61.1 basophils/microliters, respectively). We conclude that in patients with hypothyroidism the number of basophils is not statistically different from the values of basophils in healthy controls. Furthermore, the number of peripheral blood basophils in hypothyroidism is not related to the serum cholesterol level.
由于在文献中嗜碱性粒细胞增多症常与黏液性水肿相关，我们运用临床实验室的常规技术对甲状腺功能减退患者的嗜碱性粒细胞进行了评估。该研究纳入了正常人、未经治疗的甲状腺功能减退患者以及患有高脂血症的甲状腺功能正常的受试者。循环嗜碱性粒细胞的数量通过对帕彭海姆染色血涂片进行分类计数来确定。与健康对照组相比，甲状腺功能减退患者的相对嗜碱性粒细胞计数和总嗜碱性粒细胞计数均未发现差异（分别为1.0%和58.1个嗜碱性粒细胞/微升，而健康对照组分别为0.8%和50.8个嗜碱性粒细胞/微升）。伴有高胆固醇血症的黏液性水肿患者中嗜碱性粒细胞的百分比为1.0%，其绝对数量为57.6/微升；在血清胆固醇水平正常的甲状腺功能减退患者中，嗜碱性粒细胞的相对数量和绝对数量无统计学差异（分别为0.83%和61.1个嗜碱性粒细胞/微升）。我们得出结论，甲状腺功能减退患者的嗜碱性粒细胞数量与健康对照组的嗜碱性粒细胞值无统计学差异。此外，甲状腺功能减退患者外周血嗜碱性粒细胞的数量与血清胆固醇水平无关。
