丙型肝炎病毒感染是迟发性皮肤卟啉症的诱因吗？

Is hepatitis C virus infection a trigger of porphyria cutanea tarda?

作者信息

Herrero C, Vicente A, Bruguera M, Ercilla M G, Barrera J M, Vidal J, Terés J, Mascaró J M, Rodés J

机构信息

Department of Dermatology, Hospital Clinic, University of Barcelona, Spain.

出版信息

Lancet. 1993 Mar 27;341(8848):788-9. doi: 10.1016/0140-6736(93)90562-u.

DOI:10.1016/0140-6736(93)90562-u

PMID:7681135

Abstract

The causes of liver disease, ranging from fatty changes to cirrhosis and hepatocellular carcinoma, in porphyria cutanea tarda (PCT) remain unclear. We tested 100 consecutive PCT patients for antibodies to hepatitis C virus (HCV) by enzyme-linked immunosorbent assay and a recombinant immunoblot assay. 75 (79%) patients with sporadic PCT but none of 5 with familial PCT were positive. HCV RNA was found in serum of all 18 anti-HCV-positive patients tested. There were no significant differences in the prevalence of anti-HCV between treated and untreated patients or between those with and without various HCV risk factors. The frequency of anti-HCV increased with the severity of liver histology. These findings implicate HCV in the aetiology of PCT-associated liver disease.

摘要

迟发性皮肤卟啉症（PCT）中从脂肪变性到肝硬化和肝细胞癌的肝脏疾病病因仍不清楚。我们通过酶联免疫吸附测定和重组免疫印迹测定对100例连续的PCT患者进行了丙型肝炎病毒（HCV）抗体检测。75例（79%）散发性PCT患者呈阳性，但5例家族性PCT患者均为阴性。在所有检测的18例抗HCV阳性患者的血清中均发现了HCV RNA。治疗和未治疗患者之间或有和没有各种HCV危险因素的患者之间抗HCV的患病率没有显著差异。抗HCV的频率随着肝脏组织学严重程度的增加而增加。这些发现表明HCV与PCT相关肝脏疾病的病因有关。