Yamazaki Y, Kiyosawa K
Institute of Medical Science, St. Marianna University School of Medicine.
Nihon Rinsho. 1995 Jun;53(6):1468-73.
Porphyria cutanea tarda (PCT) is due to reduced activity of the enzyme uroporphyrinogen decarboxylase in hepatocyte. Hepatic dysfunction is found in almost all cases of PCT. Recently, high prevalence of hepatitis C virus (HCV) infection in patients with PCT was reported in Europe. Is HCV infection a trigger of PCT? Several cases of PCT associated with hepatitis C were reported in Japan. The frequency of anti-HCV increased with the severity of liver histology. These findings implicate HCV in the etiology of PCT-associated liver disease. Treatment with interferon should be considered for PCT with HCV infection.
迟发性皮肤卟啉症（PCT）是由于肝细胞中尿卟啉原脱羧酶活性降低所致。几乎所有PCT病例都存在肝功能障碍。最近，欧洲报道PCT患者中丙型肝炎病毒（HCV）感染的高患病率。HCV感染是PCT的触发因素吗？日本报道了几例与丙型肝炎相关的PCT病例。抗HCV的频率随肝脏组织学严重程度增加。这些发现提示HCV与PCT相关肝病的病因有关。对于HCV感染的PCT患者应考虑使用干扰素进行治疗。
