感染人类的卡氏肺孢子菌菌株中的核苷酸序列变异。
Nucleotide sequence variation in Pneumocystis carinii strains that infect humans.
作者信息
Lee C H, Lu J J, Bartlett M S, Durkin M M, Liu T H, Wang J, Jiang B, Smith J W
机构信息
Department of Pathology, Indiana University School of Medicine, Indianapolis 46202.
出版信息
J Clin Microbiol. 1993 Mar;31(3):754-7. doi: 10.1128/jcm.31.3.754-757.1993.
Abstract
The nucleotide sequences of a portion of the large-subunit mitochondrial rRNA gene of Pneumocystis carinii derived from 12 patients were examined. Five sequences were found to be identical to the prototype sequence reported by Sinclair et al. (K. Sinclair, A. E. Wakefield, S. Banerji, and J. M. Hopkin, Mol. Biochem. Parasitol. 45:183-184, 1991). Six sequences differed from the prototype sequence at one to three positions. The remaining sequence was markedly different from the prototype sequence and appeared to be a hybrid of the human and rat P. carinii sequences. The results of this study indicate the existence of multiple P. carinii strains infecting humans and suggest that coinfections of animal and human P. carinii strains in the same host are possible.
摘要
对来自12名患者的卡氏肺孢子虫线粒体大核糖体RNA基因一部分的核苷酸序列进行了检测。发现有5个序列与Sinclair等人（K. Sinclair、A. E. Wakefield、S. Banerji和J. M. Hopkin，《分子生物化学寄生虫学》45:183 - 184，1991年）报道的原型序列相同。6个序列在1至3个位置上与原型序列不同。其余序列与原型序列明显不同，似乎是人和大鼠卡氏肺孢子虫序列的杂交体。本研究结果表明存在多种感染人类的卡氏肺孢子虫菌株，并提示同一宿主中动物和人类卡氏肺孢子虫菌株的混合感染是可能的。
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本文引用的文献
1
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Am Rev Respir Dis. 1984 Dec;130(6):1161-5. doi: 10.1164/arrd.1984.130.6.1161.
2
Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies.卡氏肺孢子虫肺炎：获得性免疫缺陷综合征患者与其他免疫缺陷患者的比较。
Ann Intern Med. 1984 May;100(5):663-71. doi: 10.7326/0003-4819-100-5-663.
3
Persistence of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Evaluation of therapy by follow-up transbronchial lung biopsy.卡氏肺孢子虫肺炎在获得性免疫缺陷综合征中的持续存在。通过随访经支气管肺活检评估治疗效果。
Chest. 1985 Jul;88(1):79-83. doi: 10.1378/chest.88.1.79.
4
NHLBI workshop summary. Pulmonary complications of the acquired immunodeficiency syndrome: an update. Report of the second National Heart, Lung and Blood Institute workshop.美国国立心肺血液研究所研讨会总结。获得性免疫缺陷综合征的肺部并发症：最新情况。第二次国立心肺血液研究所研讨会报告。
Am Rev Respir Dis. 1987 Feb;135(2):504-9. doi: 10.1164/arrd.1987.135.2.504.
5
Pneumocystis carinii and Toxoplasma gondii infections in patients with AIDS.艾滋病患者的卡氏肺孢子虫和弓形虫感染。
Rev Infect Dis. 1986 Nov-Dec;8(6):1001-11. doi: 10.1093/clinids/8.6.1001.
6
Pneumocystis carinii pneumonia: diagnosis.卡氏肺孢子虫肺炎：诊断
J Infect Dis. 1988 Jun;157(6):1115-9. doi: 10.1093/infdis/157.6.1115.
7
AIDS in Africa--clinicopathological aspects.非洲的艾滋病——临床病理学方面
Trans R Soc Trop Med Hyg. 1988;82(6):801-2. doi: 10.1016/0035-9203(88)90001-6.
8
Treatment and prophylaxis of Pneumocystis carinii pneumonia.卡氏肺孢子虫肺炎的治疗与预防
Infect Dis Clin North Am. 1988 Jun;2(2):419-28.
9
Monoclonal antibodies to Pneumocystis carinii: identification of specific antigens and characterization of antigenic differences between rat and human isolates.针对卡氏肺孢子虫的单克隆抗体：特异性抗原的鉴定以及大鼠和人类分离株之间抗原差异的特征分析。
J Infect Dis. 1989 Jan;159(1):60-70. doi: 10.1093/infdis/159.1.60.
10
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