可溶性CD40配体可在T细胞依赖性激活过程中替代正常T细胞来源的CD40配体向B细胞发出的信号。
Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation.
作者信息
Lane P, Brocker T, Hubele S, Padovan E, Lanzavecchia A, McConnell F
机构信息
Basel Institute for Immunology, Switzerland.
出版信息
J Exp Med. 1993 Apr 1;177(4):1209-13. doi: 10.1084/jem.177.4.1209.
Abstract
We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells. By itself it induced a modest degree of B cell proliferation, but together with anti-immunoglobulin (anti-Ig) antibody it greatly stimulated B cell proliferation, as determined by both [3H]thymidine uptake and increase in cell numbers. These data are evidence that the CD40 ligand on T cells provides a signal that drives B cell proliferation. This signal is synergistic with that delivered by anti-Ig antibody.
摘要
我们构建了一种小鼠CD8α链与小鼠CD40 T细胞配体之间的可溶性嵌合融合蛋白。该蛋白可与人及小鼠B细胞结合。其自身可诱导适度的B细胞增殖，但与抗免疫球蛋白（抗Ig）抗体共同作用时，通过[3H]胸腺嘧啶核苷摄取及细胞数量增加测定发现，它能极大地刺激B细胞增殖。这些数据证明T细胞上的CD40配体提供了驱动B细胞增殖的信号。该信号与抗Ig抗体传递的信号具有协同作用。
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