Holzmann K, Blin N, Welter C, Zang K D, Seitz G, Henn W
Institute of Human Genetics, University of Tübingen, Germany.
Genes Chromosomes Cancer. 1993 Mar;6(3):178-81. doi: 10.1002/gcc.2870060308.
In a series of cytogenetically analyzed renal tumors of different histological types (chromophobe carcinoma, clear-cell carcinoma, chromophilic carcinoma, and oncocytoma) and normal renal tissue, the length of the telomeric DNA repeats was assessed using a (TTAGGG)3 oligonucleotide probe. A strong correlation was noted between pronounced telomere shortening and the appearance of telomeric associations of chromosomes. These data suggest an etiologic role of the loss of telomeric DNA repeats in the formation of telomeric associations and a possible involvement of this mechanism in the pathogenesis of chromosome aberrations in human tumors.
在一系列经细胞遗传学分析的不同组织学类型的肾肿瘤（嫌色细胞癌、透明细胞癌、嗜色细胞癌和嗜酸细胞瘤）以及正常肾组织中，使用（TTAGGG）3寡核苷酸探针评估端粒DNA重复序列的长度。端粒明显缩短与染色体端粒联合的出现之间存在强烈相关性。这些数据表明端粒DNA重复序列的丢失在端粒联合形成中具有病因学作用，并且该机制可能参与人类肿瘤中染色体畸变的发病过程。
