• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Activation of telomerase in a human tumor.

作者信息

de Lange T

机构信息

Rockefeller University, New York, NY 10021-6399.

出版信息

Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):2882-5. doi: 10.1073/pnas.91.8.2882.

DOI:10.1073/pnas.91.8.2882
PMID:8159672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC43476/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec9/43476/02f4b4529b4c/pnas01130-0014-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec9/43476/02f4b4529b4c/pnas01130-0014-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec9/43476/02f4b4529b4c/pnas01130-0014-a.jpg

相似文献

1
Activation of telomerase in a human tumor.人类肿瘤中端粒酶的激活。
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):2882-5. doi: 10.1073/pnas.91.8.2882.
2
Telomeres, telomerase, and cancer.
Science. 1995 May 26;268(5214):1115-7. doi: 10.1126/science.7761821.
3
Telomerase activity in human ovarian carcinoma.人卵巢癌中的端粒酶活性
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):2900-4. doi: 10.1073/pnas.91.8.2900.
4
Telomeres, telomerase, and immortality.端粒、端粒酶与永生
J Natl Cancer Inst. 1995 Jun 21;87(12):884-94. doi: 10.1093/jnci/87.12.884.
5
Chromosome ends catch fire.
Science. 1994 Sep 16;265(5179):1656-8. doi: 10.1126/science.7521969.
6
[Telomerase. The enzyme that renders the cell immortal].
Ugeskr Laeger. 1995 Aug 7;157(32):4469-70.
7
Aging, healing, and the metabolism of telomeres.衰老、愈合与端粒的代谢
Am J Hum Genet. 1993 Apr;52(4):657-60.
8
Telomerase and telomere-length regulation: lessons from small eukaryotes to mammals.端粒酶与端粒长度调控:从小型真核生物到哺乳动物的经验教训
Cold Spring Harb Symp Quant Biol. 1993;58:719-23. doi: 10.1101/sqb.1993.058.01.079.
9
Developmental and tissue-specific regulation of mouse telomerase and telomere length.小鼠端粒酶和端粒长度的发育及组织特异性调控
Proc Natl Acad Sci U S A. 1995 May 23;92(11):4818-22. doi: 10.1073/pnas.92.11.4818.
10
Telomerase and DNA end replication: no longer a lagging strand problem?端粒酶与DNA末端复制:不再是后随链问题了吗?
Science. 1995 Sep 15;269(5230):1533-4. doi: 10.1126/science.7545310.

引用本文的文献

1
Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancer.端粒酶逆转录酶(TERT/hTERT)在乳腺癌中的调控作用及其临床潜力。
Cell Commun Signal. 2023 Aug 23;21(1):218. doi: 10.1186/s12964-023-01244-8.
2
Insights into POT1 structural dynamics revealed by cryo-EM.冷冻电镜揭示端粒酶相关蛋白 1 的结构动力学见解。
PLoS One. 2022 Feb 17;17(2):e0264073. doi: 10.1371/journal.pone.0264073. eCollection 2022.
3
miR-490 suppresses telomere maintenance program and associated hallmarks in glioblastoma.

本文引用的文献

1
An alternative pathway for yeast telomere maintenance rescues est1- senescence.酵母端粒维持的另一条途径挽救了est1衰老。
Cell. 1993 Apr 23;73(2):347-60. doi: 10.1016/0092-8674(93)90234-h.
2
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.正常及21三体人类淋巴细胞衰老过程中端粒DNA的丢失。
Am J Hum Genet. 1993 Apr;52(4):661-7.
3
The dichotomy between germ line and somatic line, and the origin of cell mortality.生殖系与体细胞系的二分法以及细胞死亡的起源。
miR-490 抑制胶质母细胞瘤中端粒维持程序和相关特征。
Cell Mol Life Sci. 2021 Mar;78(5):2299-2314. doi: 10.1007/s00018-020-03644-2. Epub 2020 Sep 24.
4
Optimization and mechanism of postponing aging of polysaccharides from Chinese herbal medicine formula.中药复方多糖延缓衰老的优化及作用机制
Toxicol Res (Camb). 2020 May 11;9(3):239-248. doi: 10.1093/toxres/tfaa020. eCollection 2020 Jun.
5
Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts.端粒酶表达的瞬时诱导介导衰老并减少原代成纤维细胞的肿瘤发生。
Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):18983-18993. doi: 10.1073/pnas.1907199116. Epub 2019 Sep 3.
6
Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells.阿马拉吉·拉萨亚纳对人血单核细胞端粒酶活性和端粒长度的影响。
J Ayurveda Integr Med. 2017 Apr-Jun;8(2):105-112. doi: 10.1016/j.jaim.2017.01.007. Epub 2017 Jun 9.
7
Cell-based immunotherapy with cytokine-induced killer (CIK) cells: From preparation and testing to clinical application.细胞因子诱导的杀伤细胞(CIK)的细胞免疫疗法:从制备、检测到临床应用。
Hum Vaccin Immunother. 2017 Jun 3;13(6):1-9. doi: 10.1080/21645515.2017.1285987. Epub 2017 Feb 22.
8
Variations in telomere maintenance and the role of telomerase inhibition in gastrointestinal cancer.端粒维持的变异及端粒酶抑制在胃肠道癌中的作用
Pharmgenomics Pers Med. 2015 Dec 4;8:171-80. doi: 10.2147/PGPM.S52808. eCollection 2015.
9
Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells.Ty同源抑制因子5,一种新型的肿瘤特异性人端粒酶逆转录酶启动子结合蛋白及结肠癌细胞中的激活因子。
Oncotarget. 2015 Oct 20;6(32):32841-55. doi: 10.18632/oncotarget.5301.
10
Comparison between Platinum-Azidothymidine and Azidothymidine Effects on Bcl-2 and Telomerase Gene Expression in Rats with Hepatocellular Carcinoma.铂-齐多夫定与齐多夫定对肝癌大鼠Bcl-2和端粒酶基因表达影响的比较
Avicenna J Med Biotechnol. 2015 Apr-Jun;7(2):50-6.
Trends Genet. 1993 Jan;9(1):7-11. doi: 10.1016/0168-9525(93)90065-P.
4
Telomeric structure in cells with chromosome end associations.
Chromosoma. 1993 Jan;102(2):121-8. doi: 10.1007/BF00356029.
5
E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts.人乳头瘤病毒16型的E6蛋白能够使人类乳腺上皮细胞越过永生化的M1阶段,但无法作用于人类成纤维细胞。
Oncogene. 1993 Jun;8(6):1407-13.
6
Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells.人乳头瘤病毒永生化人肛门生殖器上皮细胞中端粒的恢复
Mol Cell Biol. 1994 Feb;14(2):961-9. doi: 10.1128/mcb.14.2.961-969.1994.
7
Transposons in place of telomeric repeats at a Drosophila telomere.果蝇端粒处的转座子取代了端粒重复序列。
Cell. 1993 Dec 17;75(6):1083-93. doi: 10.1016/0092-8674(93)90318-k.
8
Loss of a yeast telomere: arrest, recovery, and chromosome loss.酵母端粒的缺失:停滞、恢复与染色体丢失
Cell. 1993 Nov 19;75(4):729-39. doi: 10.1016/0092-8674(93)90493-a.
9
Telomerase activity in human ovarian carcinoma.人卵巢癌中的端粒酶活性
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):2900-4. doi: 10.1073/pnas.91.8.2900.
10
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.DNA链断裂:触发p53依赖性DNA损伤反应途径的DNA模板改变。
Mol Cell Biol. 1994 Mar;14(3):1815-23. doi: 10.1128/mcb.14.3.1815-1823.1994.