Katoh N, Okabayashi K, Wakabayashi S, Kishimoto S, Yasuno H
Department of Dermatology, Kyoto Prefectural University of Medicine, Japan.
J Dermatol. 1993 Feb;20(2):114-7. doi: 10.1111/j.1346-8138.1993.tb03842.x.
A 22-year-old man had had a dome-shaped tumor on his penis for one year. Neither his particular past history nor family history was available. The excised specimen contained numerous von Kossa-positive deposits. Four types of histologic pattern were identified: 1) a cystic structure filled with amorphous material lined by a few layers of epithelial cells, 2) a cyst containing calcified deposits in the keratinous material, 3) a large calcified nodule lined by attenuated epithelial cyst walls, 4) numerous calcium collections without an epithelial wall. The cystic structure showed the histologic features of syringoma or sweat duct milia. The luminal cells of the cyst showed positive immunoreactivity for both keratin and carcinoembryonic antigen. These findings suggested that the keratinous contents of syringoma had gradually calcified, the cyst wall had been attenuated, and, finally, numerous calcium collections without an epithelial wall were formed. Our case further supported the hypothesis that penile calcinosis as well as scrotal calcinosis might derive from syringoma.
一名22岁男性阴茎上出现圆顶状肿瘤已有一年。其个人既往史和家族史均不详。切除的标本中有大量von Kossa阳性沉积物。鉴定出四种组织学模式：1）一个充满无定形物质的囊性结构，内衬几层上皮细胞；2）一个在角质物质中含有钙化沉积物的囊肿；3）一个大的钙化结节，内衬变薄的上皮囊肿壁；4）大量无上皮壁的钙沉积物。囊性结构显示出汗腺瘤或汗管粟丘疹的组织学特征。囊肿的腔内细胞对角蛋白和癌胚抗原均呈阳性免疫反应。这些发现提示，汗腺瘤的角质内容物逐渐钙化，囊肿壁变薄，最终形成大量无上皮壁的钙沉积物。我们的病例进一步支持了阴茎钙化以及阴囊钙化可能源自汗腺瘤的假说。
