Grummt T, Grummt H J, Schott G
Federal Health Office, Bad Elster Branch, Germany.
Mutat Res. 1993 May;302(1):19-24. doi: 10.1016/0165-7992(93)90085-a.
The frequencies of structural chromosome aberrations of persons occupationally exposed to antineoplastic drugs without adequate protection were measured in peripheral blood lymphocytes of 106 persons from five oncological units and in an adequate control population. The observed chromosomal aberration frequencies were 3.3 +/- 0.1 aberrations per 100 cells in the exposed group and 0.6 +/- 0.1 aberrations per 100 cells in the controls. Chromosomal aberration frequencies were not correlated with age, duration of exposure and smoking habits. The results stress the necessity to protect hospital staff against the potential risk related to the handling of antineoplastic drugs.
在来自五个肿瘤科室的106名职业性接触抗肿瘤药物且未得到充分防护的人员的外周血淋巴细胞中，以及在一个适当的对照人群中，测量了染色体结构畸变的频率。暴露组观察到的染色体畸变频率为每100个细胞中有3.3±0.1个畸变，对照组为每100个细胞中有0.6±0.1个畸变。染色体畸变频率与年龄、暴露持续时间和吸烟习惯无关。结果强调了保护医院工作人员免受与处理抗肿瘤药物相关潜在风险的必要性。
