Grover I S, Bala S
Department of Botany, Guru Nanak Dev University, Amritsar, India.
Mutat Res. 1993 Jun;300(1):1-3. doi: 10.1016/0165-1218(93)90133-x.
The water and chloroform extracts of guava were tested for their antimutagenicity. The water extract was effective in inactivating the mutagenicity of direct-acting mutagens, e.g., 4-nitro-o-phenylenediamine, sodium azide, and the S9-dependent mutagen, 2-aminofluorene, in the tester strains of Salmonella typhimurium. The chloroform extract was inactive. Autoclaving of the water extract for 15 min did not reduced its activity appreciably. The enhanced inhibitory activity of the extracts on pre-incubation suggests the possibility of desmutagens in the extracts. Besides ascorbic acid and citric acid, the major constituents of the extracts, the role of other antimutagenic factors in the extracts cannot be ruled out.
对番石榴的水提取物和氯仿提取物进行了抗诱变活性测试。水提取物能有效使直接作用诱变剂（如4-硝基邻苯二胺、叠氮化钠）以及依赖S9的诱变剂2-氨基芴在鼠伤寒沙门氏菌测试菌株中的诱变性失活。氯仿提取物无活性。水提取物经15分钟高压灭菌后其活性并无明显降低。提取物在预孵育时增强的抑制活性表明提取物中可能存在抗诱变剂。除了提取物的主要成分抗坏血酸和柠檬酸外，不能排除提取物中其他抗诱变因子的作用。
