Kahramanmaraş Sütçü Imam University, Faculty of Medicine, Department of Medical Biology, 46100 Kahramanmaraş, Turkey.
Ecotoxicol Environ Saf. 2010 Oct;73(7):1553-7. doi: 10.1016/j.ecoenv.2010.07.036. Epub 2010 Aug 13.
Beauvericin, a naturally occurring contaminants of food and feeds, has been implicated in several mycotoxicoses; however, there is little information on its genotoxicity. Therefore, the genotoxic and cytotoxic effects of beauvericin in in vitro cultures of human lymphocytes were investigated with chromosome aberrations (CAs), sister-chromatid exchanges (SCEs), micronuclei (MN) as well as mitotic, proliferative and nuclear division indices. Beauvericin caused a significant concentration-dependent increase in chromosomal aberrations, sister-chromatid exchanges and micronuclei. It also significantly decreased the mitotic index at the two highest concentrations. However, no significant change in the proliferative and nuclear division indices was found. The results indicated that BEA is genotoxic to human lymphocytes in vitro.
展青霉素是一种天然存在于食物和饲料中的污染物，已被牵连到多种霉菌毒素中毒事件中；然而，关于其遗传毒性的信息却很少。因此，本研究采用染色体畸变（CAs）、姐妹染色单体交换（SCEs）、微核（MN）以及有丝分裂、增殖和核分裂指数，检测了展青霉素对人淋巴细胞体外培养的遗传毒性和细胞毒性。结果表明，展青霉素可导致染色体畸变、姐妹染色单体交换和微核显著的浓度依赖性增加，同时还显著降低了两个最高浓度的有丝分裂指数。然而，增殖和核分裂指数没有明显变化。这些结果表明 BEA 对人淋巴细胞具有遗传毒性。
