The behavioural effects of intrathecal galanin on tests of thermal and mechanical nociception in the rat.

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作者信息

Wiesenfeld-Hallin Z, Xu X J, Hao J X, Hökfelt T

机构信息

Department of Clinical Physiology, Karolinska Institute, Huddinge, Sweden.

出版信息

Acta Physiol Scand. 1993 Apr;147(4):457-8. doi: 10.1111/j.1748-1716.1993.tb09521.x.

DOI:10.1111/j.1748-1716.1993.tb09521.x

PMID:7684182

Abstract

摘要

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The behavioural effects of intrathecal galanin on tests of thermal and mechanical nociception in the rat.

Acta Physiol Scand. 1993 Apr;147(4):457-8. doi: 10.1111/j.1748-1716.1993.tb09521.x.

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Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze.甘丙肽受体亚型2（GalR2）基因敲除突变小鼠在高架十字迷宫实验中表现出一种特定的焦虑样行为表型。

Pharmacol Biochem Behav. 2007 Jan;86(1):8-20. doi: 10.1016/j.pbb.2006.11.024. Epub 2007 Jan 25.

The second galanin receptor GalR2 plays a key role in neurite outgrowth from adult sensory neurons.第二种甘丙肽受体GalR2在成年感觉神经元的神经突生长中起关键作用。

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Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.甘丙肽在脊髓中的受体亚型特异性促伤害感受和镇痛作用：通过GalR1和GalR2受体的选择性作用。

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Spinal antinociception by morphine in rats is antagonised by galanin receptor antagonists.加兰素受体拮抗剂可拮抗吗啡对大鼠的脊髓镇痛作用。

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