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Intrathecal galanin increases the latency in the tail-flick and hot-plate test in mouse.

作者信息

Post C, Alari L, Hökfelt T

机构信息

ASTRA ALAB AB, Research and Development Laboratories, Södertälje, Sweden.

出版信息

Acta Physiol Scand. 1988 Apr;132(4):583-4. doi: 10.1111/j.1748-1716.1988.tb08369.x.

DOI:10.1111/j.1748-1716.1988.tb08369.x
PMID:2465669
Abstract
摘要

相似文献

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Intrathecal galanin increases the latency in the tail-flick and hot-plate test in mouse.鞘内注射甘丙肽可延长小鼠甩尾试验和热板试验的潜伏期。
Acta Physiol Scand. 1988 Apr;132(4):583-4. doi: 10.1111/j.1748-1716.1988.tb08369.x.
2
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Intrathecal galanin antagonizes the facilitatory effect of substance P on the nociceptive flexor reflex in the rat.
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6
Apparent hyperalgesia in the mouse tail-flick test due to increased tail skin temperature after lesioning of serotonergic pathways.5-羟色胺能通路损伤后,由于尾部皮肤温度升高,小鼠甩尾试验中出现明显的痛觉过敏。
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Intrathecal injections of galanin and its antiserum affect nociceptive response of rat to mechanical, but not thermal, stimuli.鞘内注射甘丙肽及其抗血清影响大鼠对机械刺激而非热刺激的伤害性反应。
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Intrathecal galanin at low doses increases spinal reflex excitability in rats more to thermal than mechanical stimuli.低剂量鞘内注射甘丙肽对大鼠脊髓反射兴奋性的增强作用,对热刺激的反应比对机械刺激的反应更明显。
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Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic.阿片类和非阿片类成分独立地对曲马多(一种“非典型”阿片类镇痛药)的作用机制起作用。
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J Pharmacol Exp Ther. 1990 Dec;255(3):1107-16.

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A New Gal in Town: A Systematic Review of the Role of Galanin and Its Receptors in Experimental Pain.新型小镇女郎:甘丙肽及其受体在实验性疼痛中的作用的系统评价。
Cells. 2022 Mar 1;11(5):839. doi: 10.3390/cells11050839.
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Peripheral galanin receptor 2 as a target for the modulation of pain.外周甘丙肽受体2作为疼痛调节的靶点。
Pain Res Treat. 2012;2012:545386. doi: 10.1155/2012/545386. Epub 2012 Jan 24.
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Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice.抑制型甘丙肽过表达转基因小鼠伤害感受表型的特征。
Mol Pain. 2010 Oct 21;6:67. doi: 10.1186/1744-8069-6-67.
4
Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior.背根神经节中甘丙肽的转基因过表达可调节疼痛相关行为。
Proc Natl Acad Sci U S A. 2003 May 13;100(10):6180-5. doi: 10.1073/pnas.0937087100. Epub 2003 Apr 29.
5
Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.甘丙肽在脊髓中的受体亚型特异性促伤害感受和镇痛作用:通过GalR1和GalR2受体的选择性作用。
Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9960-4. doi: 10.1073/pnas.161293598. Epub 2001 Jul 31.
6
Galanin-acetylcholine interactions in rodent memory tasks and Alzheimer's disease.甘丙肽与乙酰胆碱在啮齿动物记忆任务及阿尔茨海默病中的相互作用。
J Psychiatry Neurosci. 1997 Nov;22(5):303-17.
7
Intracerebroventricular galanin and N-terminal galanin fragment enhance the morphine-induced analgesia in the rat.
J Neural Transm Gen Sect. 1995;102(3):229-35. doi: 10.1007/BF01281157.
8
Spinal antinociception by morphine in rats is antagonised by galanin receptor antagonists.加兰素受体拮抗剂可拮抗吗啡对大鼠的脊髓镇痛作用。
Naunyn Schmiedebergs Arch Pharmacol. 1994 Oct;350(4):380-6. doi: 10.1007/BF00178955.
9
Galanin antisense oligonucleotides reduce galanin levels in dorsal root ganglia and induce autotomy in rats after axotomy.甘丙肽反义寡核苷酸可降低背根神经节中的甘丙肽水平,并在大鼠轴突切断后诱导自切行为。
Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12540-3. doi: 10.1073/pnas.91.26.12540.
10
Intrathecal galanin at low doses increases spinal reflex excitability in rats more to thermal than mechanical stimuli.低剂量鞘内注射甘丙肽对大鼠脊髓反射兴奋性的增强作用,对热刺激的反应比对机械刺激的反应更明显。
Exp Brain Res. 1988;71(3):663-6. doi: 10.1007/BF00248760.