Bichko V, Pushko P, Dreilina D, Pumpen P, Gren E
FEBS Lett. 1985 Jun 3;185(1):208-12. doi: 10.1016/0014-5793(85)80771-7.
The entire genome of human hepatitis B virus (HBV) occurring in Latvia was sequenced. This sequence, which is 3182 nucleotides long, was compared with the other previously published HBV genomes and was shown to share maximum homology with HBV subtype ayw DNA. The coordinates of 4 main open reading frames as well as hairpin structures are very well conserved in the two genomes. The distribution of nucleotide substitutions among different HBV genomes suggest that the open reading frames P and X can fulfil a coding function. On the basis of primary structure comparison for hepadnaviral DNAs several evolutionary conclusions can be drawn.
对在拉脱维亚发现的人类乙型肝炎病毒（HBV）的全基因组进行了测序。该序列长度为3182个核苷酸，与之前发表的其他HBV基因组进行了比较，结果显示与HBV亚型ayw DNA具有最大同源性。两个基因组中4个主要开放阅读框以及发夹结构的坐标非常保守。不同HBV基因组之间核苷酸替换的分布表明，开放阅读框P和X可以发挥编码功能。基于嗜肝DNA病毒DNA的一级结构比较，可以得出一些进化结论。
