肠炎沙门氏菌O抗原生物合成中的糖基转移酶：B、C2和E1组转移酶基因的鉴定与表征
Glycosyl transferases of O-antigen biosynthesis in Salmonella enterica: identification and characterization of transferase genes of groups B, C2, and E1.
作者信息
Liu D, Haase A M, Lindqvist L, Lindberg A A, Reeves P R
机构信息
Department of Microbiology, University of Sydney, New South Wales, Australia.
出版信息
J Bacteriol. 1993 Jun;175(11):3408-13. doi: 10.1128/jb.175.11.3408-3413.1993.
Abstract
In Salmonella enterica, there is a great variety of O antigens, each consisting of a short oligosaccharide (the repeating unit) repeated many times. The O antigens differ in their sugar composition and glycosidic linkages. The genetic determinants of the O antigen are located in an rfb gene cluster, and some, including those of S. enterica O serogroups B, C2, and E1, have been cloned and sequenced. In this study of the glycosyltransferases which form the glycosidic linkages, we identify and characterize the four mannosyl and three rhamnosyl transferase genes of the three rfb gene clusters.
摘要
在肠炎沙门氏菌中，存在多种O抗原，每种O抗原都由一个短寡糖（重复单元）多次重复组成。O抗原在其糖组成和糖苷键方面存在差异。O抗原的遗传决定因素位于rfb基因簇中，其中一些，包括肠炎沙门氏菌O血清群B、C2和E1的那些，已经被克隆和测序。在这项关于形成糖苷键的糖基转移酶的研究中，我们鉴定并表征了三个rfb基因簇中的四个甘露糖基转移酶基因和三个鼠李糖基转移酶基因。
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