Buschard K, Madsbad S, Rygaard J
Lancet. 1978 Apr 29;1(8070):908-10. doi: 10.1016/s0140-6736(78)90684-0.
Lymphocytes extracted from peripheral-blood samples from each of six patients with newly diagnosed insulin-dependent diabetes mellitus were transplanted into arthymic nude mice. At one or more sampling times (in the thirty-day study) blood sugar was higher in mice which had received lymphocytes from diabetic patients than in the control mice which had received lymphocytes from non-diabetic donors. Blood-sugar concentrations reached 260 mg/dl in some mice in the experimental group. This study demonstrates that lymphocytes may have an aggressive role in diabetogenesis. With this mouse experimental model mechanisms involved in diabetogenesis, and probably also in other disease in which lymphocytes are suspected of being involved in pathogenesis, could be investigated.
从6例新诊断的胰岛素依赖型糖尿病患者的外周血样本中提取淋巴细胞，移植到无胸腺裸鼠体内。在一个或多个采样时间点（在为期30天的研究中），接受糖尿病患者淋巴细胞的小鼠的血糖高于接受非糖尿病供体淋巴细胞的对照小鼠。实验组的一些小鼠血糖浓度达到260mg/dl。这项研究表明，淋巴细胞可能在糖尿病发生过程中起积极作用。利用这个小鼠实验模型，可以研究糖尿病发生过程中涉及的机制，可能也适用于其他怀疑淋巴细胞参与发病机制的疾病。
