Kaneko H, Mitsuma T, Uchida K, Furusawa A, Morise K
Fourth Department of Internal Medicine, Aichi Medical University, Japan.
Am J Gastroenterol. 1993 Jun;88(6):898-904.
Changes in immunoreactive (ir)-somatostatin, substance P, and calcitonin gene-related peptide concentrations of the human gastric mucosa were examined in subjects with nonulcer dyspepsia (NUD) and peptic ulcer to clarify the relationship between these peptides and dyspeptic symptoms. Fifty-six patients with NUD were divided into two subject subgroups as follows: 22 patients with upper abdominal discomfort, nausea, and/or vomiting (motility disorder group) and 34 patients complaining of upper abdominal pain [ulcer-like disorder (UD) group]. These patients were compared with either an age- and sex-matched group of asymptomatic outpatients without any organic disease (control group: n = 51), or to a group with peptic ulcer (PU group: n = 30). Ir-somatostatin concentrations of the gastric mucosa were significantly higher in UD group than in PU, motility disorder, or control group, and ir-substance P concentrations in the UD group were higher than in the PU group. No difference in ir-calcitonin gene-related peptide concentrations was observed among the four groups. These results indicate that there may be two distinct subgroups in NUD, and that NUD is not just a stage within the spectrum of peptic ulcer disease from the viewpoint of several gastrointestinal-hormone concentrations of the human gastric mucosa.
为阐明免疫反应性（ir）-生长抑素、P物质和降钙素基因相关肽浓度与消化不良症状之间的关系，对非溃疡性消化不良（NUD）患者和消化性溃疡患者胃黏膜中这些肽的浓度变化进行了检测。56例NUD患者被分为以下两个亚组：22例有上腹部不适、恶心和/或呕吐的患者（动力障碍组）和34例主诉上腹部疼痛的患者[溃疡样障碍（UD）组]。将这些患者与年龄和性别匹配的无症状无任何器质性疾病的门诊患者组（对照组：n = 51）或消化性溃疡组（PU组：n = 30）进行比较。UD组胃黏膜中的ir-生长抑素浓度显著高于PU组、动力障碍组或对照组，UD组中的ir-P物质浓度高于PU组。四组之间在ir-降钙素基因相关肽浓度上未观察到差异。这些结果表明，NUD中可能存在两个不同的亚组，并且从人胃黏膜的几种胃肠激素浓度来看，NUD不仅仅是消化性溃疡疾病谱中的一个阶段。
