Kaneko H, Mitsuma T, Fujii S, Uchida K, Kotera H, Furusawa A, Morise K
Fourth Department of Internal Medicine, Aichi Medical University, Japan.
J Gastroenterol Hepatol. 1993 Jul-Aug;8(4):322-7. doi: 10.1111/j.1440-1746.1993.tb01521.x.
Immunoreactive-somatostatin (ir-SS) concentrations of the gastric mucosa and mood state in patients with functional dyspepsia were examined. The subjects were 12 patients with upper abdominal discomfort, nausea and/or vomiting (motility disorder group) and 14 patients complaining of upper abdominal pain (ulcer-like disorder group) for more than a month without any organic upper-gastrointestinal tract disease proven by endoscopy. These patients were compared with either an age- and sex-matched group of asymptomatic outpatients without any organic disease (control group: n = 26) or to a group of patients with peptic ulcer (n = 19). Somatostatin concentrations of the stomach were measured by radio-immunoassay, and the mood state of each subject was assessed by Manifest Anxiety Scale (MAS) and Self-rating Depression Scale test. Immunoreactive-somatostatin concentrations of the gastric mucosa were significantly higher in the ulcer-like disorder group than in the peptic ulcer, motility disorder or control group, and gastric juice levels were higher in the ulcer-like disorder group. The psychometric tests showed that the motility disorder group was more depressive than the ulcer-like disorder group, but there were no differences between the motility disorder, ulcer-like disorder and peptic ulcer group in MAS scores or environmental factors. These results indicate that there may be two different subgroups in functional dyspepsia influenced by both ir-SS concentration of the stomach and/or mood state.
检测了功能性消化不良患者胃黏膜的免疫反应性生长抑素（ir-SS）浓度和情绪状态。研究对象为12例有上腹部不适、恶心和/或呕吐的患者（动力障碍组）以及14例主诉上腹部疼痛的患者（溃疡样障碍组），他们均有超过1个月的症状，且经内镜检查未发现任何器质性上消化道疾病。将这些患者与年龄和性别匹配的无症状且无任何器质性疾病的门诊患者组（对照组：n = 26）或消化性溃疡患者组（n = 19）进行比较。通过放射免疫分析法测定胃中生长抑素的浓度，并用显性焦虑量表（MAS）和自评抑郁量表测试评估每个受试者的情绪状态。溃疡样障碍组胃黏膜的免疫反应性生长抑素浓度显著高于消化性溃疡组、动力障碍组或对照组，且溃疡样障碍组的胃液水平更高。心理测试表明，动力障碍组比溃疡样障碍组更抑郁，但动力障碍组、溃疡样障碍组和消化性溃疡组在MAS评分或环境因素方面没有差异。这些结果表明，功能性消化不良可能存在两个不同的亚组，受胃ir-SS浓度和/或情绪状态的影响。
